Anti-Ulcer Histomorphological Effect of Dr. Iguedo Goko Herbal Mixture, Esomeprazole and Ethanolic Extract of Annona Muricata (Soursop) Leaves, On Albino Rats Gastrointestinal Tract (GIT)

Abstract

The potentials in the use of plants and herbal remedies to provide newer drugs and as such are reservoirs of natural chemicals that can provide chemo protection against indomethacin (NSAIDS) induced ulcer or any form of inflammation in the GIT.  This study aimed at investigating the role of Dr. Iguedo goko cleanser, esomeprazole and ethanol extract of Soursop [A. muricata leaves] on the histomophology of the GIT [stomach and colon] in indomethacin induced ulcer in albino wister rats. Dr. Iguedo goko cleanser was sourced from the distributor in OWERRI metropolis Imo State, esomeprazole [AstraZeneca brand] was also sourced from a pharmaceutical shop in OWERRI metropolis Imo State. Maceration ethanolic method was used for A.muricata leaves.  Forty eight [48] apparently healthy albino rats of both sexes were classified into 6groups. Group 1 normal control, group 2 indomethacin, group 3, esomeprazole,  group 4 Dr. Iguedo goko cleanser,  group  5 A.muricata extract 1000mg/kg, group 6 A.muricata extract 2000mg/kg. Rats in group1were given only food and water  no treatment. Rats in group 2 were induced with indomethacin 30mg/kg once. Rats in group 3 were treated with esomeprazole after indomethacin induction.  Rats in group 4 were treated with Dr.Iguedo goko cleanser after ulcer induction. Rats in group 5were treated with 1000mg/kg of A.muricata leaves extract after ulcer induction.  Rats in group 6 were treated with 2000mg/kg of the A. muricata leaves extract after ulcer induction. The treatment lasted for 2weeks. Comparative observations of the indomethacin induced GIT, clearly  reveals  induction of histopathology/cytology alterations as evidenced by emptied goblet cells,  lacerations  and suppressed mucosa, ulceration,  destruction of surface epithelium which were not evidence in the control group .Treatment group exhibited marked repair and improvement in the histomophology of the GIT, which were better in the herbal mixture and the extract when compared with the reference drug. The result suggested that the herbal mixture and the extract of A.muricata have more promising therapeutic role against inflammation and ulceration induce in the albino rats.